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Project

Strength training to reduce nociceptor plasticity in SCI-induced pain

Funder: Craig H Neilsen Foundation

Funding period
USD 300 K
Funding amount
Abstract
Rehabilitative therapies like aerobic locomotor training, task-specific skilled training and strength training are widely used in the clinical SCI population with its primary goal to promote increased muscle strength, improvements in motor function and a greater level of independence after SCI. However, one of the most important benefits of post-SCI rehabilitation is its effects on sensory recovery. In the lab, we showed that early administration of a sustained aerobic locomotor exercise (Ex) program prevents the development of neuropathic pain in a contusive rat model of SCI. However, delaying aerobic Ex until pain was established was ineffective at ameliorating it, suggesting that the time when Ex is initiated is critical to successful suppression of neuropathic pain. This proposal aims to examine the effects of strength training exercise on nociceptor plasticity using animal models of SCI. We will determine if strength training exercise will 1) prevent the acute development of pain and/or ameliorate established pain in chronic SCI, 2) result in a normal distribution pattern of nociceptive afferents in the dorsal horn and 3) reduce spontaneous activity and hyperexcitability of nociceptive primary sensory neurons. Understanding these interactions will give us a better understanding of the neurobiology to improve the overall management of chronic neuropathic pain, and prevention of its development.The studies proposed here will provide the basis for an NIH R01 to further establish the mechanisms by which rehabilitative strategies prevent or ameliorate pain after spinal cord injury. (CHN: SCIRTS chn:wdg)
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System

Categories
  • FOR (ANZSRC)

    1103 Clinical Sciences

  • FOR (ANZSRC)

    1109 Neurosciences

  • RCDC

    Injury (total) Accidents/Adverse Effects

  • RCDC

    Injury - Trauma - (Head and Spine)

  • RCDC

    Neurosciences

  • RCDC

    Pain Research

  • RCDC

    Pain Conditions - Chronic

  • RCDC

    Rehabilitation

  • RCDC

    Spinal Cord Injury

  • RCDC

    Neurodegenerative

  • RCDC

    Peripheral Neuropathy

  • RCDC

    Physical Rehabilitation

  • RCDC

    Prevention

  • HRCS HC

    Neurological

  • HRCS HC

    Musculoskeletal

  • Health Research Areas

    Biomedical

  • Broad Research Areas

    Basic Science