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Project

Postprandial fat metabolism following an acute exercise bout in persons with spinal cord injuries

Funder: Craig H Neilsen Foundation

Funding period
USD 300 K
Funding amount
Abstract
An accelerated trajectory of cardioendocrine disease has been extensively reported in persons with spinal cord injuries (SCI). Excessive accumulation of visceral fat – a widely reported occurrence within the first year after SCI, and a major cardioendocrine component risk - is the most serious risk component for this disease. The proposed project is designed to advance our understanding of how fats from both nutritional intake and visceral depots are metabolized, and how they can be more efficiently utilized by persons with SCI. Ten adults aged 18-60 yrs with chronic (= 1 yr) tetraplegia (C5-C8, AIS A-C), 10 adults aged 18-60 years with chronic paraplegia (T6-T12, AIS A-C), and 10 adults matched for age and gender but without SCI will be tested. In a randomized cross-over design, participants will undergo a stable isotope tracer postprandial lipemia test with and without preceding aerobic exercise. Participants will complete either a seated resting control or aerobic exercise equal to 300 kcal as assessed via indirect calorimetry (approximately 45 min of exercise). Following either non-exercising control or exercise, subjects will consume 0.5 L of a liquid meal containing 20 kcal/kg FFM and 5 mg/kg FFM of stable isotope [U-13C]palmitate. Breath and arterialized blood samples will be collected at 7 time points up to 400 min post-meal for the determination of energy expenditure and rates of endogneous and exogenous fat oxidation. Additionally, blood will be analyzed for energy substrates (glucose, glycerol, free-fatty acids, triglycerides) and hormones (catecholamines and insulin). The proposed study will allow us to deploy novel stable isotopic tracer methods with the ultimate goal of developing innovative rehabilitation strategies aimed at improving the quality of life of persons with spinal cord injuries. (CHN: SCIRTS chn:wdg)
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System

Categories
  • FOR (ANZSRC)

    1103 Clinical Sciences

  • RCDC

    Injury (total) Accidents/Adverse Effects

  • RCDC

    Injury - Trauma - (Head and Spine)

  • RCDC

    Neurosciences

  • RCDC

    Nutrition

  • RCDC

    Obesity

  • RCDC

    Spinal Cord Injury

  • RCDC

    Behavioral and Social Science

  • RCDC

    Clinical Research

  • RCDC

    Neurodegenerative

  • RCDC

    Prevention

  • Health Research Areas

    Clinical

  • Broad Research Areas

    Clinical Medicine and Science