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Implanted Blood Pressure Sensor for Autonomic Dysreflexia Monitoring/Alarm

Funder: Craig H Neilsen Foundation

Funding period
USD 600 K
Funding amount
Autonomic dysreflexia (AD) is a lifelong and potentially life-threatening condition for individuals with spinal cord injury (SCI) at or above the sixth thoracic (T6) neurological level. AD is an unmodulated sympathetic reflex response to nociceptive stimuli below the level of injury resulting in an abrupt rise in blood pressure (BP) and frequently coupled with a baroreceptor-mediated reflex bradycardia. AD can result in disabling headache, seizure, stroke, myocardial ischemia/arrhythmia and death. Our overall goal is to take advantage of significant advances in technology over the past decade that will allow us to address AD; first through development of a fully implanted AD detection and alert (ADDA) system, and ultimately through development of an AD mitigation and treatment system. The central feature of the ADDA system is BP monitoring, utilizing a sensor and processor that measure BP and HR at regular intervals. The proposed BP sensor will ultimately be implanted, providing a stable recording without requiring any intervention by the user. The goal of this project is to develop the detailed design specifications for the implanted ADDA system through two Specific Aims:Specific Aim 1 - Establish the ADDA System design requirements using an acute and chronic pig model. We will test subdural PPG sensors placed in pigs to 1) determine the PPG design sensor requirements for intramuscular placement of sensors; 2) determine the necessary characteristics of sensor encapsulation; and 3) determine the signal processing requirements for accurate BP prediction, including methods can be used to automatically identify and remove movement and noise artifacts. Specific Aim 2 – Establish the ADDA System design requirements using able-bodied and SCI individuals. The goal of this aim is to evaluate the proposed BP monitoring and AD detection system on human subjects using externally applied components (to the extent possible). In addition, we will test PPG sensor signal quality intraoperatively in individuals undergoing neuroprosthesis system implantation and will test electrocardiogram (ECG) prediction with current neuroprosthesis system users. These studies will provide information regarding 1) ECG sensor design requirements; 2) consistency of BP estimation parameters; and 3) calibration requirements and frequency.At the completion of this study, we anticipate having completed all of the necessary steps to demonstrate the potential efficacy of our BP monitoring system and we will have the complete set of design requirements to proceed with design and development of the ADDA System for SCI subjects. This proposal serves as the first key component of a future system targeted at the detection, warning, alleviation, and ultimately treatment of AD in SCI. (CHN: SCIRTS chn:wdg)
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    1109 Neurosciences

  • RCDC

    Injury (total) Accidents/Adverse Effects

  • RCDC

    Injury - Trauma - (Head and Spine)

  • RCDC


  • RCDC


  • RCDC

    Spinal Cord Injury

  • RCDC




  • Broad Research Areas

    Clinical Medicine and Science