Please enable JavaScript or talk to your local administrator to get JavaScript enabled.

Project

Investigating microtubule regulation in axon and branch regeneration

Funder: Craig H Neilsen Foundation

Funding period
USD 300 K
Funding amount
Abstract
The proposed pilot study targets two areas of nerve regeneration after spinal cord injury. First, we will test a mechanism regulating axonal branch formation and understand how it affects branch sprouting and branch regeneration, two different modes of regeneration that can effectively promote functional recovery. Second, we will understand how this mechanism regulates axonal microtubules, which provide mechanical stability as well as transport tracks in axons. As recent studies have shown that stabilizing microtubules by FDA approved-drugs can promote effective axon regeneration in the rodent spinal cord, the proposed research will dissect the potential mechanism mediated by a novel microtubule associated protein 7 (MAP7). MAP7 was identified in our study of the development of dorsal root ganglion (DRG) sensory neurons. We found that MAP7 regulates microtubule stability and organelle transport during different steps of branch formation of DRG axons. These findings prompt us to investigate the role of MAP7 in regenerative potentials of axonal branches. Using an in vitro injury model, we will dissect the cellular mechanisms responsible for MAP7 function in preventing retraction and promoting growth in normal branch sprouting and in damaged nerve branches. In collaboration with my colleague Dr. Angelo Lepore, we will use a rodent spinal cord injury model involving the respiratory function to establish the in vivo function of MAP7 and determine its role in different modes of nerve regeneration. By exploring this novel intrinsic mechanism, our goal is to identify a new treatment target that can be combined with other therapeutics to promote functional recovery after spinal cord injury. As we are new to spinal cord injury research, the support from the Neilson foundation will thus provide a strong support for us to expand our investigation of a basic developmental mechanism to translational research of nerve regeneration. (CHN: SCIRTS chn:wdg)
Similar projects All >
Sorted by: Start Date
Project list item
Molecular control over motor circuit remodeling

Craig H Neilsen Foundation to Edmund Roy Hollis, Nadjat Serradj

USD 300,000
2019 - 2021
Project list item
Biological light stimulation to restore function after SCI

Craig H Neilsen Foundation to Ute Hochgeschwender, Griffin E. Kendziorski, Ute Hochgeschwender, Eric D. Petersen

USD 300,000
2019 - 2021
Project list item
Novel and potent compounds that promote axon growth

Craig H Neilsen Foundation to Vance P. Lemmon, Sixue Chen, John Bixby, Hassan Al-Ali, Marc Giulianotti

USD 600,000
2019 - 2022
Project list item
Novel chemical approaches for specific targeting of CSPGs to restore function after SCI

Craig H Neilsen Foundation to Linda Carol Hsieh-Wilson, Elizabeth Jane Bradbury

USD 600,000
2019 - 2022
Project list item
Exofocal Injury after Spinal Cord Injury - the role of chronic microgliosis

Craig H Neilsen Foundation to Jan M Schwab

USD 296,000
2019 - 2021

System

Categories
  • FOR (ANZSRC)

    1109 Neurosciences

  • RCDC

    Injury (total) Accidents/Adverse Effects

  • RCDC

    Injury - Trauma - (Head and Spine)

  • RCDC

    Regenerative Medicine

  • RCDC

    Neurosciences

  • RCDC

    Spinal Cord Injury

  • RCDC

    Neurodegenerative

  • HRCS HC

    Neurological

  • HRCS RAC

    1.1 Normal biological development and functioning

  • HRCS RAC

    2.1 Biological and endogenous factors

  • Health Research Areas

    Biomedical

  • Broad Research Areas

    Basic Science