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Project

Microbiome-based Interventions for SCI-induced Gastrointestinal Dysfunction

Funder: Craig H Neilsen Foundation

Funding period
USD 256 K
Funding amount
Abstract
Alterations to the gastrointestinal (GI) microbiome (i.e. dysbiosis) can lead to detrimental effects on GI functions. Spinal cord injury (SCI) has been demonstrated to trigger dysbiosis in both rodent models and human incidences. Experimental data indicate that SCI-provoked microbiome alterations correlate with increased intestinal inflammation and permeability. However, whether the dysbiosis following SCI has direct effects on GI motility and function is unknown. Approximately 40% of persons with SCI suffer from functional constipation, with increased transit time and decreased fecal water content. Given the importance of microbial signals in mediating GI transit, via interactions with enteroendocrine cells in the GI tract, it is interesting to consider that dysbiosis may directly contribute to constipation after SCI. We hypothesize that dysbiosis following SCI triggers decreased GI transit throught interaction with enteroendocrine cells, and that dietary intervention will ameliorate dysbiosis and drastically improve functional GI outcomes. Here, we will characterize functional changes to both the microbiome and enteroendocrine cells in a mouse model of clinically relevant SCI, establish causality of microbiome signals on GI transit, and determine a dietary intervention to reestablish the GI microbiome and restore GI function following SCI. ( chn:wdg)
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System

Categories
  • FOR (ANZSRC)

    1109 Neurosciences

  • RCDC

    Injury (total) Accidents/Adverse Effects

  • RCDC

    Injury - Trauma - (Head and Spine)

  • RCDC

    Digestive Diseases

  • RCDC

    Nutrition

  • RCDC

    Spinal Cord Injury

  • RCDC

    Neurodegenerative

  • HRCS HC

    Oral and Gastrointestinal

  • HRCS RAC

    2.1 Biological and endogenous factors

  • Health Research Areas

    Biomedical

  • Broad Research Areas

    Basic Science