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Project

The role of lipid dysfunction in spinal cord injury pathophysiology

Funder: Craig H Neilsen Foundation

Funding period
USD 599 K
Funding amount
Abstract
Individuals with spinal cord injury suffer from cardiovascular disease at higher rates than able-bodied individuals. This increased prevalence is often assumed due to decreased activity and increased muscle wasting with spinal cord injury. Presumably, the sedentary lifestyle causes excess lipid, or cholesterol, accumulation in macrophages. Lipid-laden macrophages, or foam cells, potentiate atherosclerosis and are key mediators of spinal cord injury secondary injury processes. We have preliminary data indicating that spinal cord injury itself triggers the formation of dysfunctional lipids that cause foam cell formation. We hypothesize that spinal cord injury triggers lipid dysfunction that contributes to the long-term cardiovascular and intraspinal pathophysiology of injury. (CHN: SCIRTS chn:wdg)
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System

Categories
  • FOR (ANZSRC)

    1109 Neurosciences

  • RCDC

    Atherosclerosis

  • RCDC

    Injury (total) Accidents/Adverse Effects

  • RCDC

    Injury - Trauma - (Head and Spine)

  • RCDC

    Cardiovascular

  • RCDC

    Heart Disease

  • RCDC

    Spinal Cord Injury

  • RCDC

    Neurodegenerative

  • HRCS HC

    Cardiovascular

  • HRCS RAC

    2.1 Biological and endogenous factors

  • Health Research Areas

    Biomedical

  • Broad Research Areas

    Basic Science