Please enable JavaScript or talk to your local administrator to get JavaScript enabled.

Project

Spasticity after Spinal Cord Injury

Funder: Craig H Neilsen Foundation

Funding period
USD 150 K
Funding amount
Abstract
After spinal cord injury (SCI), damage to descending motor pathways has been associated with the development of spasticity. However, which descending motor pathways influence spasticity following SCI, and to what extent, remains poorly understood. This proposal has two main goals: 1) to examine the contribution of cortico- and reticulo-spinal pathways to spasticity in upper-limb muscles, and 2) to develop strategies to promote functional recovery of upper-limb spastic muscles in humans with incomplete cervical SCI. In Aim 1, we propose to use transcranial magnetic stimulation and startle acoustic stimuli to examine the contribution of the cortico- and reticulo-spinal pathway to biceps and triceps muscles electromyographic activity. Spinal cord atrophy and morphological characterization of cortico- and reticulo-spinal pathways will be assessed with high-resolution magnetic resonance imaging. Physiological and neuroimaging outcomes will be associated with clinical assessment of spasticity. In Aim 2, we propose to enhance cortico- and reticulo-spinal contribution to reach-to-grasp function in upper-limb spastic muscles by using a novel intervention combining startle acoustic stimuli with motor training. The proposed research will provide new knowledge about the contribution of descending motor pathways to the control of spasticity in upper-limb muscles following incomplete cervical SCI (Aim 1) and might lead to the development of a novel rehabilitation intervention to improve upper-limb motor function recovery by enhancing residual descending control over spinal networks (Aim 2). Receiving this award will allow Dr. Sangari to receive training in neurophysiology, neuroimaging, and neuromodulation in humans with and without SCI, providing him with a unique skillset to become an independent investigator in the field of neurorehabilitation. (CHN: SCIRTS chn:wdg)
Similar projects All >
Sorted by: Start Date
Project list item
Single-Cell Transcriptome and Epigenome of Regenerating CST Neurons

Craig H Neilsen Foundation to Jae Mun Kim, Binhai Zheng

USD 150,000
2020 - 2022
Project list item
Activating dI3 interneurons to promote recovery of locomotor function

Craig H Neilsen Foundation to Tuan Vu Bui, Alex Laliberte, Iroshan Hewage, Sara Goltash

USD 300,000
2020 - 2022
Project list item
SCI Pharmacovigilance: neurologic drug safety in spinal cord injury

Craig H Neilsen Foundation to Jacquelyn Cragg, Andrei Krassioukov, Brian K Kwon, Catherine Jutzeler, Fred Geisler, Jan Rosner, Rick Hansen

USD 297,000
2020 - 2022
Project list item
Elucidation of Mechanisms Behind Renal Dysfunction After Spinal Cord Injury

Craig H Neilsen Foundation to Veronica Tom, Patrick Osei-Owusu

USD 300,000
2020 - 2022
Project list item
The role of lipid dysfunction in spinal cord injury pathophysiology

Craig H Neilsen Foundation to John Carib Gensel, Alan Daugherty, Katherine Thompson, Kevin Hatton

USD 599,000
2020 - 2023

System

Categories
  • FOR (ANZSRC)

    1109 Neurosciences

  • RCDC

    Injury (total) Accidents/Adverse Effects

  • RCDC

    Injury - Trauma - (Head and Spine)

  • RCDC

    Regenerative Medicine

  • RCDC

    Neurosciences

  • RCDC

    Rehabilitation

  • RCDC

    Spinal Cord Injury

  • RCDC

    Clinical Research

  • RCDC

    Neurodegenerative

  • RCDC

    Physical Rehabilitation

  • HRCS HC

    Neurological

  • Health Research Areas

    Biomedical

  • Broad Research Areas

    Basic Science